ParkinsonCanadaV1, Main, Exploration, bibRecord, 003D21

l-DOPA regulates glutamate decarboxylases mRNA levels in MPTP-treated monkeys

Identifieur interne : 003D21 ( Main/Exploration ); précédent : 003D20; suivant : 003D22

l-DOPA regulates glutamate decarboxylases mRNA levels in MPTP-treated monkeys

Auteurs : Jean-Jacques Soghomonian [Canada] ; Sophie Pedneault [Canada] ; Pierre J. Blanchet [Canada] ; Martin Goulet [Canada] ; Thérèse Di Paolo [Canada] ; Paul J. Bédard [Canada]

Source :

Molecular Brain Research [ 0169-328X ] ; 1996.

RBID : ISTEX:2E84E5F78EA7FADEA2AFE3F77B8DD8F66B6C1CD5

Descripteurs français

Pascal (Inist)
- Animal, Antiparkinsonien, Corps strié, Dopa, Expression génique, Forme moléculaire, GABA, Glutamate decarboxylase, Neurotoxine, Parkinson maladie, Pyridine(1-méthyl-4-phényl-1,2,3,6-tétrahydro), Singe.
Wicri :
- topic : Singe.

English descriptors

KwdEn :
- Animal, Antiparkinson agent, Corpus striatum, Dopa, GABA, Gene expression, Glutamate decarboxylase, Molecular form, Monkey, Neurotoxin, Parkinson disease.

Abstract

The effect of dopaminergic denervation, alone or followed by chronic intermittent l-DOPA administration, on the levels of mRNAs encoding for the two isoforms of the GABA-synthesizing enzyme, glutamate decarboxylase (GAD65 and GAD67), were measured by in-situ hybridization in the caudate and putamen of macaque monkeys. When compared to control monkeys, the level of GAD67 mRNA was increased in the putamen and caudate of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. On the other hand, GAD65 mRNA labeling in MPTP-treated monkeys was not significantly different from the controls. In MPTP-treated monkeys that received l-DOPA, a significant increase in both GAD67 and GAD65 mRNA levels was measured in the putamen when compared to control or MPTP-treated monkeys. The results suggest that the dyskinetic effect of l-DOPA is paralleled by an increased GABAergic activity in the striatum.

Url:

https://api-v5.istex.fr/document/2E84E5F78EA7FADEA2AFE3F77B8DD8F66B6C1CD5/fulltext/pdf

DOI: 10.1016/0169-328X(96)00078-2

Affiliations:

Canada

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<front><div type="abstract" xml:lang="en">The effect of dopaminergic denervation, alone or followed by chronic intermittent l-DOPA administration, on the levels of mRNAs encoding for the two isoforms of the GABA-synthesizing enzyme, glutamate decarboxylase (GAD65 and GAD67), were measured by in-situ hybridization in the caudate and putamen of macaque monkeys. When compared to control monkeys, the level of GAD67 mRNA was increased in the putamen and caudate of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. On the other hand, GAD65 mRNA labeling in MPTP-treated monkeys was not significantly different from the controls. In MPTP-treated monkeys that received l-DOPA, a significant increase in both GAD67 and GAD65 mRNA levels was measured in the putamen when compared to control or MPTP-treated monkeys. The results suggest that the dyskinetic effect of l-DOPA is paralleled by an increased GABAergic activity in the striatum.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

l-DOPA regulates glutamate decarboxylases mRNA levels in MPTP-treated monkeys

l-DOPA regulates glutamate decarboxylases mRNA levels in MPTP-treated monkeys

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
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